Prenatal exposure to halogenated, aryl, and alkyl organophosphate esters and child neurodevelopment at two years of age

Neurotoxicity of organophosphate esters (OPEs) has been reported in toxicological studies, but epidemiological findings are limited. We aimed to assess the associations between prenatal OPE exposures and children’s neurodevelopment at 2 years old. measured urinary concentrations OPEs collected first third trimester from 184 pregnant women Wuhan, China. Childhood was assessed using Chinese revision Bayley Scale Infant Development. A two-fold increase average bis (1,3-dichloro-2-propyl) phosphate (BDCIPP) associated with 3.50 decrease Psychomotor Development Index (PDI) score (95%CI: ?5.86, ?1.14) 5.75 Mental (MDI) ?8.94, ?2.55). Average molar chlorinated-alkyl (?Cl-OPEs) during pregnancy inversely PDI [? = ?3.24 ?5.95, ?0.53)] MDI scores ?5.86 ?9.52, ?2.20)]. Prenatal BDCIPP ?Cl-OPEs were boys, not girls. Our study provides evidence that elevated exposure especially might be childhood neurodevelopment, effect seems sex-specific.